pelviperineology. 2013; 32(3): 67-71 | DOI:

Collagen contents variations between different stages of anterior vaginal wall prolapse

ANDRÉS MARAMBIO¹, CÉSAR SANDOVAL¹, RAÚL VALDEVENITO¹, MICHEL NASER¹, VALENTÍN MANRÍQUEZ¹, RODRIGO GUZMÁN¹, JORGE LECANNELIER¹, JAIME JANS¹, AMALIA AGUILERA¹, GUILLERMO DÍAZ^2
1Female Pelvic Floor Unit, Obstetric and Gynecology Service, University of Chile Clinical Hospital, ²Pharmacological and Toxicological Department, Chemistry and Pharmacy Faculty, University of Chile

Objective: :Vaginal prolapse is a common disease, whose etiology is not well understood. Many studies have focused on alterations in the levels of collagen would present these patients, yielding conflicting results. Aim of the study: To measure the amount of types I and III collagen found in the connective tissue lining the vagina among patients with anterior vaginal wall prolapse and compare it with patients without prolapse and between different clinical stages of prolapse.
Materials and Methods: :Cross-sectional study. Statistical analysis was carried out considering a statistical power of 80% and an alpha level of 5%.
Results: :A total of 84 patients in different stages as per natural distribution were recruited. The mean patient age was 53,9 ± 11 years (32-78). We didn´t find significant differences in the levels of type I and type III collagen, between the various stages of prolapse or when comparing with the control group.
Conclusion: :Our histological findings in the endopelvic fascia reveal that there would be no changes in the levels of type I and type III collagen between the different stages of genital prolapse, so it would not meet an etiological role in the development of this pathology

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Cite This Article

MARAMBIO A, SANDOVAL C, VALDEVENITO R, NASER M, MANRÍQUEZ V, GUZMÁN R, LECANNELIER J, JANS J, AGUILERA A, DÍAZ G. Collagen contents variations between different stages of anterior vaginal wall prolapse. 2013; 32(3): 67-71

Corresponding Author: MARAMBIO A.

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