Introduction: :HPV infection is a very common sexually transmitted disease. Studies regarding anal infection in men, typically focus on HIV-immunosuppressed subjects or men who have sex with men.
Objective: :To evaluate the prevalence of anal HPV in infertile patients with infected semen and to detect the genotype concordance and most prevalent types at both sites.
Methods: :In 118 infertile patients with positive FISH analysis for HPV on semen, sperm parameters were compared with those of 172 infertile noninfected men serving as control group for semen analysis. In the former group, detection and genotyping of HPV infection was performed by INNO-LiPA assay in semen and anal brushes.
Results: :Sperm parameters from infected males showed significantly reduced motility and increased anti-sperm antibodies compared with controls (P<0.001 and P<0.01). HPV DNA detection and typing in semen showed HPV-16 as the most prevalent genotype (24.6%). Anal brushing tested positive 47 subjects (39.8%) showing high concordance with seminal HPV types. In this group, 7 patients (14.9%) had anal warts and 23.4% had a coinfection by more HPV types. Most prevalent HPV type observed in patients with anal infection was HPV-6 (24.4%).
Conclusions: :This study demonstrates for the first time that HPV semen infection may represent a risk factor for anal HPV even in heterosexual asymptomatic men. Because the strong associacion between anal cancer, anal warts and HPV infection, we suggest testing the anal site of patients with semen infection and to counsel them in order to prevent warts and cancer development.
Corresponding Author: GAROLLA A.|